2015 Fiscal Year Final Research Report
Analysis of the onset mechanism of myelomonocytic leukemia by GATA2 deficiency
| Project/Area Number |
26860204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Harada Nobuhiko 東北大学, 医学(系)研究科(研究院), 助教 (20431439)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 単球性白血病 |
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| Outline of Final Research Achievements |
Gata2 knockdown(KD) mice showed no abnormality in complete blood count but these mice showed monocytosis with aging, like chronic myelomonocytic leukemia patients.By using a colony-forming unit(CFU) assay, the propotion of CFU-M(monocyte) from Gata2 KD bone marrow was increased. The gene expression of Csf1 receptor and IL-6 receptor was increased in granulocyte-macrophage progenitors(GMPs) from Gata2 KD bone marrow. These results suggested that GMPs from Gata2 KD has a potential to promote aberrant monocytic differentiation.
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| Free Research Field |
分子生物学
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