2015 Fiscal Year Final Research Report
Neuronal cell surface mechanisms which induce dystrophic endball
| Project/Area Number |
26860209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 軸索再生 / オートファジー / チロシンフォスファターゼ |
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| Outline of Final Research Achievements |
Heparan sulfate and chondroitin sulfate are sulfated glycans which are involved in axonal elongation in our central nervous system. Although they share the same neuronal receptor PTPσ, how they differentially regulate it is still unknown. Here, minimum essential structures of heparan sulfate and chondroitin sulfate were successfully identified. In both glycans, tetrasaccharide is the shortest structure to interact with PTPσ. However, interestingly, the probability of the structures is quite rare in chondroitin sulfate, while quite rich in heparan sulfate. These findings account for how heparan sulfate and chondroitin sulfate work in opposing manner on PTPσ and axonal elongation.
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| Free Research Field |
生化学
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