2015 Fiscal Year Final Research Report
Biological activity of galectin-4 and its roles in colorectal cancer and normal tissue.
| Project/Area Number |
26860213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ガレクチン / 大腸がん / 消化管 / レクチン |
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| Outline of Final Research Achievements |
Galectin-4 is a major galectin isoform existed in the digestive tract, and it may contribute to the differentiation of epithelial cell. Recently, many immunohistochemical studies have shown that the galectin-4 is highly expressed in normal tissues, but decreased in the adenoma and the invasion front of colonic cancers. These facts suggest that the galectin-4 has specific activity, which might be involved in tumor suppression. However, the direct correlation between disappearance of galectin-4 and its molecular mechanism of tumor inhibition remain to be understood. To investigate the role of galectin-4 in tumor growth, we prepared the stable transfectants of galectin-4 in human colonic cancer cells (CRCs). Then, we found that overexpression of the galectin-4 suppresses growth of CRCs. Furthermore, knockdown of galectin-4 resulted in an increased CRCs proliferation. These results suggest that galectin-4 contributes to the suppression of colorectal cancer.
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| Free Research Field |
細胞生物学
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