2016 Fiscal Year Final Research Report
Establishment of mitophagy imaging method
| Project/Area Number |
26860219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Juntendo University |
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Principal Investigator |
Inoshita Tsuyoshi 順天堂大学, 医学(系)研究科(研究院), 助教 (20601206)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | パーキンソン病 / 神経科学 / シナプス小胞 / Vps35 |
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| Outline of Final Research Achievements |
Neural function of Parkinson’s disease causative genes, PINK1 and Parkin were analyzed by using Drosophila model. Molecular genetical methods, immunostaining and live imaging showed that abnormal activity of Parkin affect accumulation of mitochondria in dopamine neurons. Neural activity were decreased by up-/down-regulation of Parkin activity and neural cell death were occurred. These results suggested that PINK1, Parkin mediated mitochondria clearance mechanisms is important for neural activity and viability.
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| Free Research Field |
神経科学
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