2015 Fiscal Year Final Research Report
Imputation-based genome-wide association study of sarcoidosis
| Project/Area Number |
26860226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human genetics
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| Research Institution | Yokohama City University |
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Principal Investigator |
MEGURO Akira 横浜市立大学, 医学(系)研究科(研究院), 特任講師 (60508802)
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| Research Collaborator |
MIZUKI Nobuhisa
OHNO Shigeaki
PETREK Martin
KASTNER Dan
NANBA Reiko
SATO Mayuki
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | サルコイドーシス / 遺伝子 / GWAS / imputation |
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| Outline of Final Research Achievements |
Sarcoidosis is a chronic multi-systemic inflammatory disorder. In this study, to identify new susceptibility genes of sarcoidosis, we performed an imputation-based genome-wide association study (GWAS) of sarcoidosis using a Japanese population. After the imputed GWAS stage, we performed a replication study using independent Japanese and Czech populations. This study found some new susceptibility genes of sarcoidosis.
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| Free Research Field |
分子遺伝学
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