2016 Fiscal Year Final Research Report
Analysis of pathogenesis using NGS in Merkel cell carcinoma associated polyomavirus
| Project/Area Number |
26860238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | メルケル細胞癌 / MCPyV / Immunohistochemistry / CADM1 / Hedgehog signal経路 / JAK-STAT経路 |
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| Outline of Final Research Achievements |
Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor that occurs most often in elderly patients. Approximately 80% of MCCs harbor Merkel cell polyomavirus (MCPyV), thought to be a carcinogenic agent. In this study, MCPyV-negative MCCs significantly expressed higher CADM1 and lower MAL than MCPyV-positive MCCs and related to unfavorable outcomes in MCCs. In hedgehog signaling pathway, increased SHH and GLI1 expression was associated with better prognosis. JAK-STAT signaling pathway was expressed in MCCs. Therefore, we suggest that these factors may play a important role in tumorigenesis of MCCs.
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| Free Research Field |
医歯薬学
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