2016 Fiscal Year Final Research Report
The significance of primary cilia in pancreatic cancer
| Project/Area Number |
26860246
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Keio University |
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Principal Investigator |
Emoto Katsura 慶應義塾大学, 医学部(信濃町), 助教 (40570859)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | primary cilia / 膵癌 / 悪性度 / 腫瘍形成能 / 細胞株 / RNAi |
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| Outline of Final Research Achievements |
The study focuses on primary cilia, which is one of the cellular organelles and can be formed in pancreatic cancer cells. Pancreatic cancer with primary cilia is recently recognized as a high-grade one, however, the mechanism is unclear. In this study, we clarify that IFT88 and KIF3A, which are necessary to form primary cilia, are related to colony formation in vitro and tumor formation in vivo.
These results reflect the character of pancreatic cancer with primary cilia; relatively well-differentiated morphology and the high ability of lymph node metastases. Our results are expected to contribute to analysis of the aggressiveness and the exploitation of novel therapeutic targets for pancreatic cancer.
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| Free Research Field |
人体病理
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