2015 Fiscal Year Final Research Report
Elucidation of role and function for cell polarity in Hair follicle stem cells through hemidesmosomal components
| Project/Area Number |
26860258
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 組織幹細胞 |
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| Outline of Final Research Achievements |
Cell polarity plays important functional roles in differentiation and proliferation of mammalian stem cells. However, the function and regulation of cell polarity in hair follicle stem cells (HFSCs) are unclear. COL17A1 is one of the hemidesmosomal transmembrane proteins that play a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal integrity. Previously, we showed that COL17A1 is essential for maintenance of hair follicle stem cells (Cell Stem Cell 2011), that the maintenance of COL17A1 in HFSCs orchestrates the stem cell centric aging program of the epithelial mini-organ (Matsumura et al. Science 2016). In this study, we are investigating how COL17A1 and ITGA6 regulates the fate of hair follicle stem cells by focusing on cell polarity.
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| Free Research Field |
医歯薬学
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