Regulation of Wnt signaling in the development of gastric cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860261
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Nagoya University
• Principal Investigator: Takagishi Maki 名古屋大学, 医学系研究科, 研究機関研究員 (10723918)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Wntシグナル / 胃がん / Daple

Outline of Final Research Achievements

We analyze which intracellular signals are activated during the development and progression of gastric cancer. When cancer cells infiltrate and metastasize, its motility has been increased by the non-canonical Wnt signaling pathway. Here we have discovered that the intracellular scaffold protein Daple controls cell motility by the non-canonical Wnt signaling in gastric cancer cells. Daple depletion also suppressed liver metastasis in a mouse xenograft model of gastric cancer.
These results suggest that the non-canonical Wnt signaling pathway contributes to gastric cancer progression at least in part via Daple, which provides a new therapeutic opportunity for the treatment of the disease.

Free Research Field

分子生物学