2015 Fiscal Year Final Research Report
Establishment of a novel therapeutic method for multiple sclerosis via plasmablasts
Project/Area Number |
26860262
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
|
Research Institution | Osaka University |
Principal Investigator |
Matsumoto Masanori 大阪大学, 免疫学フロンティア研究センター, 特任助教 (50542106)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 多発性硬化症 / IL-10 / plasmablast |
Outline of Final Research Achievements |
B cells can suppress experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis, by secreting an anti-inflammatory cytokine, IL-10. However, whether human plasmablasts can also serve as predominant IL-10 producers remains unknown. By culturing peripheral blood B cells derived from healthy donors in vitro, we found that plasmablasts predominantly produced IL-10 and that their IL-10 production was mediated by activation of IRF4 and NFAT. Thus, these results suggest that human plasmablasts can serve as IL-10 producers to suppress multiple sclerosis.
|
Free Research Field |
医歯薬学
|