2016 Fiscal Year Final Research Report
The development of malaria vaccine platform using baculovirus regulating immune responses
| Project/Area Number |
26860278
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | マラリアワクチン |
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| Outline of Final Research Achievements |
We have developed the malaria-vaccine platform using several kinds of modified baculovirus such as complement resistant baculovirus, dendritic targeting baculovirus, decoy-receptor expressing baculovirus, cytokine expressing baculovirus and shRNA expressing baculovirus. Among them, complement resistant baculovirus and cytokine expressing baculovirus worked very well in functional analyses. When immunized in mice, these baculovirus induced strong anti-malaria antibody response and conferred high protective efficacy against the infection with transgenic rodent malaria.
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| Free Research Field |
微生物学・免疫学
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