Identification of novel myeloid ITAMRs that recognize Mycobacterium tuberculosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860292
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Kagoshima University
• Principal Investigator: Iizasa Ei'ichi 鹿児島大学, 医歯学域医学系, 助教 (20631998)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 結核 / ITAM / 自然免疫 / 受容体

Outline of Final Research Achievements

For the identification of novel myeloid ITAM-coupled receptors (mITAMRs) that recognize Mycobacterium tuberculosis (M. tuberculosis), we have screened ITAMR library. As the result, we identified two novel ITAMRs, IgSFR2 and IgSFR5. In addition, We have identifed the ligands of the receptors. MA-containing lipids are the ligands for IgSFR2 and cardiolipin is that for IgSFR5. Furthermore, we have analyzed the function of IgSFR2 and found that IgSFR2 recognizes the ligands and plays important roles in the regulation of immune response against M. tuberculosis for the eradication of the infection.

Free Research Field

免疫学