Signals of epithelial cells facilitate to translocation of Pseudomonas aeruginosa through the epithelial tissues

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860295
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: Hayashi Naoki 京都薬科大学, 薬学部, 助教 (70707463)
• Research Collaborator: GOTOH Naomasa 京都薬科大学, 薬学部, 教授 (30121560)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 感染症 / 細菌 / 緑膿菌 / 上皮細胞 / トランスロケーション / 鞭毛 / ムチン

Outline of Final Research Achievements

The prevention and treatment of opportunistic infections with immunocompromised host are required in the developed countries including Japan. The colonization of Pseudomonas aeruginosa in respiratory, urinary, and gastrointestinal tracts in immunocompromised patients can trigger a wide range of severe acute and chronic infectious diseases. In particular, translocation of the colonized P. aeruginosa through epithelial tissues, which are covered with mucin, can cause severe bacteremia leading to fatal sepsis. Here, we found that P. aeruginosa, which was induced the acceleration of flagellar motility by the smaller protein secreted from epithelial cells, can penetrate the mucin layer. Further studies will be required to clarify the translocation mechanisms in P. aeruginosa, our studies could lead to new therapeutic strategies for P. aeruginosa gut-derived sepsis.

Free Research Field

基礎医学 細菌学 病原性