Development of therapeutic measures against hantavirus infection using animal model

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860298
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Hokkaido University
• Principal Investigator: Shimizu Kenta 北海道大学, 医学研究科, 助教 (20466840)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: CD8陽性T細胞

Outline of Final Research Achievements

Although host immunity is thought to be involved in the pathogenesis of hantavirus infection, the mechanism remains to be elucidated. In this study, I tried to identify immune cells relating to the disease development of hantavirus infection using a mouse model and a technique to deplete specific immune cells by antibody administration. As a result, I found that CD8+ T cells that have an important role in cell-mediated immunity were involved in the disease development of hantavirus infection. I anticipate that CD8+ T cells will be a possible target for the therapeutic measures for hantavirus infection.

Free Research Field

微生物学