Design of vaccine antigen focused on the epitopes recognized by broad neutralizing antibodies

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860304
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: 一般財団法人阪大微生物病研究会
• Principal Investigator: Inoue Yuji 一般財団法人阪大微生物病研究会, 研究部 探索研究課, 主任 (90548869)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ワクチン / インフルエンザ

Outline of Final Research Achievements

In this study, we attempted to construct a vaccine complex to protect infection from a broad range of influenza viral strains. Here we focused on the "stem region" in the hemagglutinin protein on the surface of influenza virion. The stem region is known to be less-variable but less-accessible compared to another part called "head region". To increase accessibility of the stem region, we prepared recombinant HA proteins and tried to bind them onto the surface of nanoparticles through the head region, on which HA molecules are inverted to expose the stem region.

Free Research Field

ウイルス学