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2015 Fiscal Year Final Research Report

Molecular biological approach to epigenetic abnormalities in inflammation-associated cancers.

Research Project

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Project/Area Number 26860318
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionTokyo Institute of Technology

Principal Investigator

Isobe Tomoyasu  東京工業大学, 大学院生命理工学研究科, 科学研究費研究員 (40402341)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywordsエピジェネティクス / 慢性炎症
Outline of Final Research Achievements

Chronic inflammation is known to be an important risk factor in cancer. Both global hypomethylation and site-specific hypermethylation in genomic DNA are observed in cancer, and it is believed that these abnormal DNA modifications disturb normal gene expression and affect genomic stability. Recently, we found that activation-induced cytidine deaminase (AID), which ectopically express in various inflammation-associated cancers including Helicobacter pylori-associated gastric cancer, activates methylated promoters and perturbs tumor-related gene expression (Isobe et al, 2013 FEBS Lett.), though the mechanisms which influence these modifications are yet to be defined. In this study, we performed shRNA library screening to reveal the mechanism by which AID induced DNA hypomethylation.

Free Research Field

分子生物学

URL: 

Published: 2017-05-10  

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