Role of sialylated IgG and novel therapeutic strategy in rheumatoid arthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860321
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Nagoya University
• Principal Investigator: Ohmi Yuhsuke 名古屋大学, 医学(系)研究科(研究院), 特任助教 (10584758)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 関節リウマチ / 自己抗体 / シアル酸 / N型糖鎖 / CIA / IgG / ST6Gal1

Outline of Final Research Achievements

Although IgG molecule has single N-glycosylation site in the Fc region and various glycosylation patterns have been reported, their functions have been unclear. Then, we have established ST6Gal1-deficient mice lines lacking sialic acids specifically in activated B cells, and have tried to induce experimental arthritis in them. Consequently, it has been demonstrated that sialylation-deficient mice exhibit exacerbation of RA features compared to wild type mice. On the other hand, administration of sialylated auto-antibody IgG into RA-model mice resulted in rather suppression of clinical features of RA.

Free Research Field

生化学、糖鎖生物学、免疫学