Crystallographic analysis of the MHC class I:lipopeptide complex and identification of the lipopepitide-angigen presentation pathway

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860323
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: Morita Daisuke 京都大学, ウイルス研究所, 助教 (40706173)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: MHCクラス1 / リポペプチド / ミリスチン酸修飾 / HIV / 抗原提示

Outline of Final Research Achievements

A new pathway for host defense has recently been discovered in the monkey AIDS model, in which lipopeptide-specific T cell responses develop to combat against infection. However, the molecular mechanisms underlying lipopeptide antigen (Ag) presentation remain elusive. In this study, we identified a lipopepide-Ag presenting rhesus MHC class I molecule, Mamu-B*098. A high-resolution X-ray crystallographic analysis of the Mamu-B*098:lipopeptide complex reveals the detailed binding manner (Morita et al. Nature Communications 2016, doi:10.1038/ncomms10356).

Free Research Field

免疫学