2015 Fiscal Year Final Research Report
The role of S100A8 and S100A9 in the pathogenesis of atopic dermatitis
| Project/Area Number |
26860326
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
Nakajima Saeko 京都大学, 医学(系)研究科(研究院), 研究員 (70574408)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | アトピー性皮膚炎 / S100A8 / S100A9 |
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| Outline of Final Research Achievements |
We aimed to generate keratinocyte specific S100A8 and S100A9 transgenic mice to understand the roles of these S100 proteins in the pathogenesis of atopic dermatitis (AD).
We have generated epidermal keratinocyte specific S100A8 and S100A9 transgenic mice. We are able to induce over expression of S100 proteins with primary cultured-keratinocytes of these mice by adding tetracycline in vitro. Skin dendritic cells and murine bone marrow derived dendritic cells (BMDCs) are highly expressed functional receptors of these S100 proteins. Recombinant S100 proteins are able to induce inflammatory cytokine productions from BMDCs in vitro.
We will apply murine AD model to keratinocyte specific S100A8 and S100A9 transgenic mice and try to understand the roles of S100A8 and S100A9 in the development of AD.
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| Free Research Field |
皮膚科学
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