2016 Fiscal Year Final Research Report
Analysis of the mechanisms underlying maintaining of intestinal CX3CR1high macrophages homeostasis
| Project/Area Number |
26860330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
Kayama Hisako 大阪大学, 医学系研究科, 助教 (40548814)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 炎症性腸疾患 / 自然免疫 |
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| Outline of Final Research Achievements |
We identified that transcription factor Spi-C highly express in intestinal CX3CR1high macrophages. In addition, Spi-C inhibited expression of colitogenic pro-inflammatory cytokines IL-6 and IL-1a mRNA through the disruption of IRF5/NF-kB p65 heterodimer formation by directly interacting with IRF5 and thereby maintaining intestinal homeostasis.
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| Free Research Field |
粘膜免疫
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