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2015 Fiscal Year Final Research Report

A study on Th2 and IgE responses in the airway allergic diseases.

Research Project

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Project/Area Number 26860340
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionHyogo Medical University

Principal Investigator

Matsushita Kazufumi  兵庫医科大学, 医学部, 講師 (20581549)

Research Collaborator YOSHIMOTO TOMOHIRO  兵庫医科大学, 医学部, 教授 (60241171)
Project Period (FY) 2014-04-01 – 2016-03-31
KeywordsIgE / Th2 / 気道 / アレルギー
Outline of Final Research Achievements

We investigated the mechanisms underlying IgE responses induced by particulate allergen exposure in lungs. We showed that B-cell-intrinsic MyD88 signaling activated by endogenous ligands, IL-1α, IL-1β, and IL-18, played a critical role in the antigen-specific IgE responses in lungs exposed to pollen allergens.
In addition, we investigated a novel role of Th2 cells in allergic airway diseases. Using an OVA-specific Th2 cells adoptive transfer model, we found that nasal CD4+ T cell activation followed by endotoxin exposure elicited IgE-independent rhinitis symptoms. This study shows the presence of T-cell-dependent and non-IgE-mediated nasal hypersensitivity-like reaction in mice.

Free Research Field

基礎医学・免疫学

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Published: 2017-05-10  

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