Critical role for differentiation and maintenance of B-1 cells by transcriptional regulator Menin

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860343
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Osaka University (2015); The Institute of Physical and Chemical Research (2014)
• Principal Investigator: Shinnakasu Ryo 大阪大学, 免疫学フロンティア研究センター, 特任助教 (00451758)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: B－１細胞 / B細胞

Outline of Final Research Achievements

B-1 cells, which have repertoires showing the cross reactivity to various pathogens in advance, perform an important role in the early stage of infection of the defense mechanism. Although the function of B-1 cells has been elucidated well so far but differentiation and maintenance mechanism of B-1 cells were not progressing. In this project, I have identified the transcriptional regulator Menin as a candidate gene involved in differentiation and maintenance of B-1 cells. From the analysis using B cell specific Menin deficient mice, significantly reduction of of B-1 cells number and reduction of titers of natural antibodies were revealed in Menin deficient mice. As a function of Menin to differentiation and maintenance of B-1 cells, it is revealed that Menin has a critical role for the survive or maintenance of precursor cells of B-1 cells.

Free Research Field

免疫