Use of hematopoietic stem cell transplantation registry data to challenge the drug lag

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical sociology
• Research Institution: Nagoya University
• Principal Investigator: Kuwatsuka Yachiyo 名古屋大学, 医学部附属病院, 病院助教 (00720509)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ドラッグラグ / レジストリデータ / 造血幹細胞移植 / 移植後合併症 / 難治性疾患

Outline of Final Research Achievements

We aimed to investigate the use of the unapproved or off-label drugs for hematopoietic stem cell transplantation and analyzed the Japanese nation level registry data. (1) We retrospectively analyzed the data of 39144 patients who received allogeneic stem cell transplantation. Chemotherapeutic agent, immunosuppressive drugs, anti-invective drugs were extracted and coded. The annual trends in the number of patients who used each unapproved or off-label drugs were obtained. (2) We analyzed the data of umbilical cord blood transplant and unrelated bone marrow transplant in 272 adults with aplastic anemia, and reported the transplant outcomes with information of the use of the off-label drugs.

Free Research Field

疫学、血液内科学