2017 Fiscal Year Final Research Report
Development of a novel bone-targeting anti-osteoporotic agent
| Project/Area Number |
26860359
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Hokuriku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | EphrinB2 / 骨粗鬆症 / 骨芽細胞 / 破骨細胞 / 骨ターゲティング / 酸性オリゴペプチド |
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| Outline of Final Research Achievements |
Osteoporosis is associated with a decrease in bone mass, which is maintained by bone-forming osteoblasts and bone-resorbing osteoclasts. We demonstrated that ephrinB2 increased osteoblastic differentiation and decreased osteoclastic differentiation in vitro, and that intravenously injected ephrinB2 ameliorated the bone loss observed in osteoporotic mice. Moreover, we constructed bone-targeting ephrinB2, named as AcOP-ephrinB2, to maximize the therapeutic effect against osteoporosis. However, high dose of AcOP-ephrinB2 showed little anti-osteoporotic effect in osteoporotic mice, that is, long-term and large-amount of accumulation of AcOP-ephrinB2 in bone appeared to be disadvantage in the treatment for osteoporosis.
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| Free Research Field |
薬理学
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