Development of universal biomarkers for multiple myeloma using novel PDGFRalpha transcript as index

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860361
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Hyogo Medical University (2015-2016); Gunma University (2014)
• Principal Investigator: Minato Yusuke 兵庫医科大学, 医学部, 助教 (00710245)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: PDGFRα

Outline of Final Research Achievements

The aim of this study is to identify a transcript of the platelet-derived growth factor receptor α (PDGFRα) gene which specifically expresses in multiple myeloma. We found five novel first exons of the human PDGFRα gene although a multiple myeloma-specific transcript was not identified. It has been reported that a gene expression system by alternative first exons is involved in a spatio-temporal expression of the gene. Thus we identified mouse homologues of the first exons and their expression was examined. The first exons showed a different tissue expression patterns, suggesting that the expression of the PDGFRα gene is precisely regulated by its first exons.

Free Research Field

細胞生物学