2015 Fiscal Year Final Research Report
The first step for elucidation of mechanism of asthma with eosinophilic chronic rhinosinusits and establishment of Airway Medicine
| Project/Area Number |
26860377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
|
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 好酸球性副鼻腔炎 / ステロイド抵抗性 / ホスファターゼ / 重症喘息 |
|---|
| Outline of Final Research Achievements |
Eosinophilic chronic rhinosinusitis (ECRS) with asthma is known as refractory and recurrence-prone disease. In particular, ECRS patients with severe asthma had elevated levels of fractionated exhaled nitric oxide and reduced response to corticosteroids. Corticosteroid sensitivity was reduced in both bronchial epithelial cells located near inflammatory site and peripheral blood mononuclear cells. Impaired proteins (some phosphatases) involved in regulation of glucocorticoid receptor function may be one of mechanisms.
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| Free Research Field |
気道炎症・アレルギー
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