2016 Fiscal Year Final Research Report
New tachykinin receptor mediates pruriceptive processing in the spinal cord
| Project/Area Number |
26860384
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 痒み / 痛み / 脊髄 / オーファン受容体 / サブスタンスP |
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| Outline of Final Research Achievements |
Tachykinin peptides represented by substance P (SP) share common amino acid sequences at the C-terminal end, F-X-G-L-M, an essential amino acids motif for their wide physiological functions. Whereas the functions of hemokinin-1 (HK-1), a new tachykinin peptide may work as a neurotransmitter as well as SP, but the details of its functions are still unclear.
We previously showed that HK-1 may play a critical role in itch transduction and the HK-1-preferred receptor may mediate itch signal in the spinal dorsal horn. Recently we found HK-1-preferred receptor based on amino acid homology to SP receptor, NK1R. Here we aim to clarify the involvement of HK-1-preferred receptor in itch processing mediated by HK-1.
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| Free Research Field |
疼痛学
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