2015 Fiscal Year Final Research Report
The roles of glycosphingolipids in neuropathic pain.
| Project/Area Number |
26860385
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | スフィンゴ脂質 / ガングリオシド / 疼痛 / 鎮痛 |
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| Outline of Final Research Achievements |
Gangliosides that are sialic acid containing-glycosphingolipids are abundant in neural tissues and previous studies revealed important roles in neuronal functions. However, the roles of gangliosides in pain sensing remain unclear. We reported that gangliosides induced hyperalgesia via glutamate signaling in skin tissues. Thus, we investigated gangliosides composition in neuropathic pain and inflammatory pain models. Complex gangliosides were increased in skin tissues from inflammatory pain model mice. Furthermore, intraplantar injection of sialidase which cleave sialyl residues of glycoconjugates including gangliosides reduced mechanical allodynia caused by inflammation. These findings suggested that gangliosides are involved in mechanical allodynia in inflammatory pain.
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| Free Research Field |
脂質生化学、疼痛学
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