2015 Fiscal Year Annual Research Report
Novel adjuvant method of malignant brain tumor diagnosis and therapy with targeted nanoparticles made of high-Z elements
| Project/Area Number |
26860393
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ザボロノク アレクサンドル 筑波大学, 附属病院, 病院講師 (20723117)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | glioma / radiotherapy / gold nanoparticles / BNCT |
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| Outline of Annual Research Achievements |
The original design of the study was modified to use accelerator-based neutron irradiation and gold nanoparticles combined with boron compounds for boron neutron capture therapy (BNCT). T98G cells were incubated with 0, 10, 20, or 40 ppm of BPA or boric acid and 50 nm gold nanoparticles to evaluate the absorbed neutron dose in the samples. The cells were placed in a phantom made of organic glass under the lithium target of the proton accelerator and irradiated for 1-2 hours with 2.0-2.3 MeV proton energy, 1-3 mA proton current, and 50-300 million events of epithermal neutron generation. The activation of gold in the samples was measured using a gamma spectrometer. The accumulation of gold in the cells was observed by electronic microscopy and measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES). The boron dose was estimated by Monte Carlo simulation from gold nanoparticle activation data. The cell survival data confirm the efficacy of the proton accelerator with the lithium target to produce a sufficient number of neutrons to initiate the boron neutron capture reaction within and close to tumor cells. The new approach in dosimetry for BNCT in the current study may allow us to determine the absorbed neutron dose using combined boron compounds containing an additional high-Z element. This approach may open up a new perspective in boron compound distribution and treatment efficacy evaluation that may lead to modification of such methods as isotope scanning and positron emission tomography (PET).
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[Presentation] Hyaluronic acid-melanin based boron-gold nanoparticles for combined neutron capture therapy and absorbed dose evaluation2015
Author(s)
Alexander Zaboronok, Sergey Taskaev, Sergej Uspenskii, Tetsuya Yamamoto, Kei Nakai, Mikhail Selyanin, Evgeniya Svidchenko, Nikolay Surin, Alexander Zelenetskii, Akira Matsumura
Organizer
8th Young Researchers BNCT Meeting
Place of Presentation
Pavia, Italy
Year and Date
2015-09-10 – 2015-09-19
Int'l Joint Research
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[Presentation] Hyaluronic Acid-based Nanomaterials for Combined Boron Neutron-Photon Capture Therapy2015
Author(s)
Alexander Zaboronok, Kei Nakai, Tetsuya Yamamoto, Sergej Uspenskii, Fumiyo Yoshida, Mikhail Selyanin, Evgeniya Svidchenko, Nikolay Surin, Alexander Zalenetskii, Akira Matsumura
Organizer
The 15th International Congress of Radiation Research (ICRR 2015)
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan
Year and Date
2015-05-25 – 2015-05-29
Int'l Joint Research
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