Investigation on molecular epidemiology and clinical features of diarrheal viruses including emerging strains in Indonesia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860434
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: The University of Tokyo
• Principal Investigator: TAKANASHI Sayaka 東京大学, 大学院医学系研究科(医学部), 助教 (20645709)
• Co-Investigator(Renkei-kenkyūsha): USHIJIMA Hiroshi 日本大学, 医学部, 上席研究員 (10091068) ; OKITSU Shoko 日本大学, 医学部, 客員研究員 (10082215)
• Research Collaborator: KALESARAN Angela ; THONGPRACHUM Aksara
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 急性胃腸炎 / ロタウイルス / ノロウイルス / 小児 / インドネシア

Outline of Final Research Achievements

Four hundred and forty one fecal specimens were collected from hospitalized pediatric patients and screened for diarrheal viruses by RT-PCR. Nine target viruses were detected in 262 out of 441 (59.4%) samples. Group A rotavirus (59.5%), followed by norovirus GII (16.4%), were the most predominant viral agents. Other viruses such as astrovirus (3.8%), sapovirus (2.7%), human parechovirus (2.7%), enterovirus (2.3%), adenovirus (2%), norovirus GI(1.1%), and Aichi virus (0.2%) were also detected. Rotavirus cases were found throughout the year, with two peaks in April and September. G1P[8] strain was the most prevalent (69.5%) G-P combination, followed by G3P[8] (16.8%). This study confirmed the diversity of viruses causing acute gastroenteritis among pediatric patients in Indonesia, with group A rotavirus being the most predominant viral agents. They emphasize the importance of introducing rotavirus vaccines in Indonesian children as a prevention strategy to reduce the disease burden.

Free Research Field

小児感染症