Metabolism of organo-arsenic in seafood in an artificial gastrointestinal system

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860442
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Chiba Institute of Science
• Principal Investigator: Hata Akihisa 千葉科学大学, 危機管理学部, 講師 (10433690)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 海産食品 / 食品衛生 / 有機ヒ素化合物 / 硫化ヒ素化合物 / 腸内細菌叢 / 化学形態別分析

Outline of Final Research Achievements

Seafood contains organic arsenic compounds such as arsenosugar (AsSug) and arsenolipid (AsLipid). The mechanisms of elution and metabolism of these arsenics in the human gastrointestinal tract are not clearly understood. In the present study, we observed the amount of arsenic elution from wakame seaweed and the metabolism of the AsSug and AsLIpid in a in vitro artificial gastrointestinal system. In this result, the human enteric bacteria increased the amount of eluted arsenic from wakame seaweed. After artificial digestion, not DMA but several AsSugs and an unidentified arsenic compound were detected. These results suggested that the AsSug and AsLipid are absorbed from the gastrointestinal tract and then metabolically converted to DMA in liver.

Free Research Field

衛生学