Investigation of the effect of arsenic on the cholesterol metabolism

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Kagoshima Women's Junior College (2015-2016); Jikei University School of Medicine (2014)
• Principal Investigator: Takumi Shota 鹿児島女子短期大学, その他部局等, 准教授 (80570770)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ヒ素 / ABCA1 / コレステロール

Outline of Final Research Achievements

Recent epidemiological studies suggest that arsenic exposure involved in atherosclerosis. In this study, we focused on the effect of arsenic on the cholesterol metabolism by using Hepa1c1c7 and HepG2 cells. The gene expression and Western Blot analysis showed that arsenic suppress the expression of ATP-binding cassette transporter-A1 (ABCA1) which involved in HDL biogenesis. Furthermore, arsenic induced the accumulation of cellular cholesterol. These results suggest that arsenic disrupt the cholesterol efflux through the inhibition of the expression of ABCA1.

Free Research Field

衛生学