2016 Fiscal Year Final Research Report
The effects of sympathetic nervous system on progression of alcoholic liver disease and chronic drinking in hypertensive individuals
| Project/Area Number |
26860466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Research Collaborator |
LIU Jinyao 山口大学, 大学院医学系研究科, 講師 (60379956)
FUJIMIYA Tatsuya 山口大学, 大学院医学系研究科, 教授 (50219044)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アルコール性肝障害 / 高血圧 / 交感神経系 / 高血圧自然発症ラット / 肝星細胞 |
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| Outline of Final Research Achievements |
We examined the effects of hypertension on the progression of alcoholic liver injury using the spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto rat (WKY) as control. As a result, chronic ethanol treatment in SHR induced hepatosteatosis with liver injury and sympathetic hyperactivity, as evidenced by increased in the accumulation of fatty droplets within hepatocytes and pericellular hepatic fibrosis with liver injury, increased in gene or protein expressions such as activated hepatic stellate cells, TNF-α, TGF-β1,collagen, adrenergic α receptor, neuropeptide Y and tyrosine hydroxylase. These results suggested that chronic ethanol treatment in SHR could induce the more severe liver injuries. In conclusion, chronic alcohol intake and hypertension could be possible to deteriorate mutually each pathological state via the sympathetic overactivity.
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| Free Research Field |
法医学（法医病理学、法医中毒学）、アルコール医学
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