2017 Fiscal Year Final Research Report
Investigation on involvement of anaphylactoid reaction in amniotic fluid embolism
| Project/Area Number |
26860470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Kanazawa Medical University (2016-2017)
St. Marianna University School of Medicine (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 羊水塞栓症 / アナフィラクトイド反応 / アナフィラトキシン / 肥満細胞 / 血液凝固機能 |
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| Outline of Final Research Achievements |
The pathophysiology of amniotic fluid embolism is thought to be anaphylactoid-like (anaphylactoid) reaction caused by inflow of amniotic fluid into the maternal circulation, but it has not been experimentally verified. In this study, we examined the effect of amniotic fluid intravenous administration on the blood components of pregnant rats, and the influence of amniotic fluid exposure on mast cells, the main constituent of anaphylactic reaction. As a result, no significant fluctuation of were observed in anaphylatoxin (C3a, C5a) and C1 inhibitor in pregnant rats administered amniotic fluid. In addition,cultured mast cells exposed to amniotic fluid did not induced degranulation. On the other hand, D-dimer increased significantly in the amniotic fluid administration group, suggesting that thrombus formation occurs by intravenous injection of amniotic fluid. Therefore, it was suggested that amniotic fluid affected blood coagulation function.
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| Free Research Field |
法医学
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