Elucidation of common mechanism for the development of metabolic and locomotive syndrome

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860489
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Keio University
• Principal Investigator: HIRATA TAKUMI 慶應義塾大学, 医学部(信濃町), 特任助教 (00383795)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨代謝マーカー / 骨密度 / インスリン抵抗性 / 高分子量アディポネクチン / 肥満 / 疫学研究

Outline of Final Research Achievements

We clarified the association between various factors related to metabolic syndrome and bone mineral density or markers for bone metabolism. Neither insulin resistance nor high-molecular-weight adiponectin level was significantly associated with bone mineral density, and body mass index was strongly confounded these associations in men and postmenopausal women. Marker levels for bone metabolism, such as BAP or TRACP-5b, decreased in order of postmenopausal women, men, and premenopausal women. TRACP-5b levels, marker for bone absorption, were increased with age in men and premenopausal women, but TRACP-5b levels were decreased in postmenopausal women with over 70 years. On the other hand, BAP levels, marker for bone formation, were decreased with age in postmenopausal women. In addition, BAP levels were significantly higher in obese participants irrespective of gender and menopausal status, and TRACP-5b levels were significantly lower in postmenopausal obese women.

Free Research Field

疫学