2016 Fiscal Year Final Research Report
The effect of sirtuin on the pathogenesis of hepatitis B virus-related liver disease
Project/Area Number |
26860491
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | B型肝炎ウイルス / 肝線維化 |
Outline of Final Research Achievements |
Hepatitis B virus (HBV) can cause chronic infection in the liver. It can lead to chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Cellular aging may be associated with HBV-related liver diseases. Knockdown of sirtuins, genes associated with age-related diseases, was associated with the activity of hepatic stellate cell. HBV replication altered the activity of hepatic stellate cell. Cellular aging assay suggested that X protein expression may have a potential to alter cellular aging. Lack of sirtuin using CRISPR/Cas system affected HBV replication. The results suggested that sirtuin may have a role in HBV-related liver disease.
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Free Research Field |
ウイルス性肝疾患
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