2016 Fiscal Year Final Research Report
Molecular function of repetitive RNA which accerelates pancreatic carcinogenesis
| Project/Area Number |
26860492
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ノンコーディングRNA / 膵がん |
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| Outline of Final Research Achievements |
We focus on repetitive RNAs which are aberrantly expressed in pancreatic cancer tissue and showed their biological significance during oncogenic process. Mouse repetitive RNAs start to be expressed from pre-cancer benign tumor. The rates of random mutation and malignant transformation are increased in repetitive RNA-overexpressing precancer cells due to impairment of DNA damage repair machinery. These results suggest that repetitive RNA functions as "intrinsic mutagen" and accerelates oncogenic process.
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| Free Research Field |
消化器内科
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