2015 Fiscal Year Final Research Report
Molecular mechanism of gastric carcinogenesis through restricted dedifferentiation by Helicobacter pylori CagA
| Project/Area Number |
26860495
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUJII YUMIKO 東京大学, 医学(系)研究科(研究院), 特任助教 (30722334)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ヘリコバクター・ピロリ / 化生 |
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| Outline of Final Research Achievements |
Chronic infection with cagA-positive Helicobacter pylori is associated with gastric diseases including gastritis, metaplasia and carcinoma. In this project, we demonstrated that CagA protein induces precancerous mucosal lesion defined as spasmolytic polypeptide expressing metaplasia (SPEM) in mouse gastric corpus. We also found that CagA deregulates the phosphorylation status of the E-cadherin cytoplasmic domain in gastric epithelial cells.
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| Free Research Field |
分子腫瘍学
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