Relationship between non-alcoholic fatty liver disease and hepatic retinoid signaling

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860498
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Gifu University
• Principal Investigator: Shirakami Yohei 岐阜大学, 医学(系)研究科(研究院), 助教 (50632816)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: レチノイド / 脂肪肝

Outline of Final Research Achievements

The phenotype of transgenic mice (dnRXR mice) whose retinoid X receptor (RXR) signaling is inhibited in a dominant negative manner was investigated. The mice exhibited significantly impaired glucose tolerance when they were fed high-fat diet. The mice also showed marked hepatic steatosis and liver injury in both drug- and diet-induced obesity models. These results suggest that dnRXR mice present glucose intolerance and steatohepatitis due to the stimulation to induce obesity, indicating RXR signaling may play a role in glucose metabolism and hepatic steatosis.

Free Research Field

消化器内科