2016 Fiscal Year Final Research Report
Effect of miR-122 expression on liver cancer stem cells properties
| Project/Area Number |
26860513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MIUMA Satoshi 長崎大学, 病院(医学系), 助教 (30437892)
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肝細胞癌 / miR-122 / 癌幹細胞 |
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| Outline of Final Research Achievements |
MicroRNA-122 (miR-122), a highly abundant and liver-specific miRNA, plays important role in liver disease. In this study, we elucidated the effect of miR-122 on liver cancer stem cells. MiR-122 overexpression decreased the ratio of hepatoma cells positive for CD44, but not other cancer stem cells surface marker, in flow-cytometry analysis. In addition, miR-122 overexpression induced lower proliferation of hepatoma cells positive for CD44. miR-122 may be a target for liver cancer stem cell therapy.
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| Free Research Field |
肝臓病学
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