2016 Fiscal Year Final Research Report
The mechanism of new photodynamic therapy targeting cancer stem cell with glycoconjugated chlorin
| Project/Area Number |
26860520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
TANAKA Mamoru 名古屋市立大学, 大学院医学研究科, 研究員 (80617861)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Photodynamic therapy / Cancert Stem Cell / c-Myc / Glut1 |
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| Outline of Final Research Achievements |
Photodynamic therapy (PDT) consists of the administration of a photosensitizer together with visible light irradiation at a specific wavelength to activate the photosensitizer, leading to the conversion of molecular oxygen to various highly reactive oxygen species (ROS), which either kill tumor cells directly or damage the tumor- associated vasculature. G-chlorin (glycoconjugated chlorin; glucose-linked tetra (fluorophenyl) chlorin) has been developed as a new type of photosensitizer. In the current study, we show that PDT with a new photosensitizer, G-chlorin
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| Free Research Field |
消化器内科
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