2016 Fiscal Year Final Research Report
Establishment of a new liver regeneration therapy by suppression of NOTCH1
| Project/Area Number |
26860523
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 肝再生 / NOTCH1 / 肝前駆細胞 |
|---|
| Outline of Final Research Achievements |
Liver originally possesses a strong capacity for regeneration. However, once a strong liver injury occur, this potential is strongly inhibited. In this situation, it has been clarified that hepatic progenitor cells (HPC) can expand and differentiate into hepatocytes to rescue the loss of liver volume. We have focused on NOTCH1 which controls HPC differentiation efficiency. By a blockade of NOTCH1, we found that HPC-mediated hepatocyte differentiation and efficiency of liver regeneration were improved in a mouse liver injury model. Therefore, inhibition of NOTCH1 can be a new strategy for a new liver regeneration therapy.
|
| Free Research Field |
肝臓病学
|
