2015 Fiscal Year Final Research Report
Mechanism of intestinal tumor formation through ADAM10
| Project/Area Number |
26860528
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
Matano Mami 慶應義塾大学, 医学部, 研究員 (20439889)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 下部消化管学 |
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| Outline of Final Research Achievements |
Our research group generated an epithelium specific ADAM10 knock-out mice through crossing ADAM10 flox mouse with villin-CreER mice. Tamoxifen induced knock out resulted in increased goblet cells and decreased intestinal stem cells. This can be explained by increased stem cell differentiation.
ADAM10 is involved in Notch signal activation through degradation of the intracellular domain. Indeed, ADAM10 knock-out intestinal epithelium inactivated Notch signal, resulting in loss of intestinal stem cells.
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| Free Research Field |
消化器内科学
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