The crosstalk between Liver fibrosis and Hepatocellular carcinoma in the point of FAP and DPP4

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860535
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kawasaki Medical School
• Principal Investigator: Nishina Sohji 川崎医科大学, 医学部, 講師 (70550961)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: CD26/DPP4 / 肝細胞癌

Outline of Final Research Achievements

CD26 expression was correlated with cell proliferation, angiogenesis and cell differentiation in HCC specimens obtained from patients. DPP-4 inhibitor did not affect cell proliferation or cell cycle in vitro. However in nude mice, DPP-4 inhibitor significantly suppressed the growth of xenograft tumors in dose dependent manner. DPP-4 inhibitor also induced NK cells infiltrations more vigorously and reduced angiogenesis in xenograft tumors, even though body weight and dietary intake through the feeding period, and glucose tolerance determined at the 14th day of feeding were not different among three groups. These results suggested that DPP-4 inhibitor potentially have antitumor activity against HCC.

Free Research Field

Hepatology