2015 Fiscal Year Final Research Report
Is FGFR2 fusion real target for bile tract cancer patients?
| Project/Area Number |
26860537
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Shunsuke Kondo 国立研究開発法人国立がん研究センター, その他部局等, 研究員 (90546201)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 胆道がん / FGFR / 融合遺伝子 / 分子標的治療 |
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| Outline of Final Research Achievements |
In vitro assay using with cell lines of bile tract cancer, we conducted the stable of overexpression with FGFR2 fusion (FGFR2-AHCYL1& FGFR2-BICC1). We validated dephosphorylation of the stable cell lines. On the other hands, several biological changes were not observed between overexpression model and endogenous cell lines. Therefore, we have challenged established cell lines from the surgical specimens. In parallel, we have detected FGFR gene mutations and FGFR fusion genes using next generation sequencer. The clinical project, TOP-GEAR project, has been on going that screening of genomic profiles and matching target therapies.
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| Free Research Field |
Gastroenterology
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