2015 Fiscal Year Final Research Report
The role of autophagy in gastrointestinal carcinogenesis
| Project/Area Number |
26860538
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The Institute for Adult Diseases Asahi Life Foundation |
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Principal Investigator |
Kosuke Sakitani 公益財団法人朝日生命成人病研究所, その他部局等, その他 (60631299)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 大腸癌 / オートファジー / 小胞体ストレス / アポトーシス / p53 / 分子標的治療 / クロロキン / HCT116 |
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| Outline of Final Research Achievements |
We showed that suppression of autophagy in colon cancer cells caused anti-tumor effects via enhanced apoptosis through p53 and unfolded protein response (UPR) activation. In addition, our study implies that suppressing UPR pathway is a valid strategy when colon cancer cells with mutant p53 are resistant to autophagic inhibition.
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| Free Research Field |
消化器内科学
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