The clinical usefulness of immuno-inflammatory biomarkers for ischemic heart disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860543
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: SAKAMOTO Aiko 東京大学, 保健・健康推進本部, 助教 (00721854)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 臨床心臓学 / バイオマーカー

Outline of Final Research Achievements

The association between cardiac disease and serum IgG4 levels was analyzed. Serum levels of IgG4 had a significant association with coronary low-density plaque and epicardial fat volume. Patients with elevated serum IgG4 levels who were not angiographically diagnosed with coronary artery stenosis had a significantly higher subsequent risk of cardiovascular events than those without. In addition, among patients who received percutaneous coronary interventions, elevated serum IgG4 level was a significant predictor of major adverse cardiac events, including death, acute coronary syndrome, cerebral stroke, and target vessel revascularization, independent of traditional cardiovascular risk factors and serum hsCRP levels. IgG4-related immuno-inflammation may play a role in the development and progression of coronary atherosclerosis.

Free Research Field

医歯薬学