2015 Fiscal Year Final Research Report
The clinical usefulness of immuno-inflammatory biomarkers for ischemic heart disease
Project/Area Number |
26860543
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
SAKAMOTO Aiko 東京大学, 保健・健康推進本部, 助教 (00721854)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 臨床心臓学 / バイオマーカー |
Outline of Final Research Achievements |
The association between cardiac disease and serum IgG4 levels was analyzed. Serum levels of IgG4 had a significant association with coronary low-density plaque and epicardial fat volume. Patients with elevated serum IgG4 levels who were not angiographically diagnosed with coronary artery stenosis had a significantly higher subsequent risk of cardiovascular events than those without. In addition, among patients who received percutaneous coronary interventions, elevated serum IgG4 level was a significant predictor of major adverse cardiac events, including death, acute coronary syndrome, cerebral stroke, and target vessel revascularization, independent of traditional cardiovascular risk factors and serum hsCRP levels. IgG4-related immuno-inflammation may play a role in the development and progression of coronary atherosclerosis.
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Free Research Field |
医歯薬学
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