2016 Fiscal Year Final Research Report
The role of STIM1 in vascular endothelial cells in the progression of atherosclerosis
| Project/Area Number |
26860547
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 血管内皮 / カルシウム / 高血圧 / 動脈硬化 |
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| Outline of Final Research Achievements |
We explored the function of STIM1, the sensor of the store of the intracellular calcium in the vascular endothelial cells (EC) and the role for the progression of atherosclerosis. We generated EC-specific STIM1 knockout mice (KO) . In the endothelial cells from KO, store-operated calcium entry, the activity of endothelial nitric oxide synthase, and nitric oxide production were significantly suppressed. Endothelial function examined by aortic ring was also significantly suppressed by EC-specific STIM1 depletion. Moreover, KO mice exhibited the active time-dominant increase in blood pressure. In addition, we explored the induction of oxidized LDL receptors by TNFα as a marker of pro-atherosclerotic reaction. Contrary to expectations, the reaction was suppressed in ECs from KO.
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| Free Research Field |
高血圧
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