Development of cardiomyocyte committed progenitor cell therapy for cardiac regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860554
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: Takeda Masafumi 京都大学, iPS細胞研究所, 研究員 (40547501)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 心臓再生

Outline of Final Research Achievements

We found a cell surface molecule successfully marked a cell population with features of cardiomyocyte-committed progenitors (we tentatively called the molecule as CCP). We generated CCP+ cardiac progenitor cell sheet and transplanted it to rat MI model. As a result, we observed cardiomyocytes derived from CCP+ cardiac progenitor cells within injured heart. These results suggested that CCP+ cardiac progenitor cells transplantation might be a promising therapy for cardiac regeneration.

Free Research Field

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