Development of cardiac regenerative drug therapy recruiting endogenous cardiac stem/progenitor cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860555
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: Fukushima Hiroyuki 京都大学, 学内共同利用施設等, 研究員 (10713860)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 心臓再生 / ケミカルバイオロジー / ES/iPS細胞

Outline of Final Research Achievements

Previously, we identified CDC1 which induced cardiomyocyte differentiation from ES/iPS cells. This study aimed development of cardiac regenerative drug therapy with utilizing CDC1. Following term were investigated; 1) Structure-activity relationship among CDC1 analogs, 2) Identification of compounds having synergistic effect with CDC1, 3) Development of gelatin hydrogel particle containing CDC1. We successfully identified some analogs showing same effect, comparing with CDC1. Although, we could not identify a new synergistic effect compound, fortunately we obtained a compound, which was hopeful drug for therapeutic use, unlike CDC1. Furthermore we are investigating utility of gelatin hydrogel particle containing CDC1.

Free Research Field

幹細胞生物学